Behind strain names like Charlotte’s Web and Haleigh’s Hope are stories of children whose epileptic seizures were dramatically reduced through medical cannabis. But while evidence so far has been anecdotal, doctors this week are presenting the first scientific studies to back them up.
At the American Epilepsy Society meeting in Philadelphia, researchers are unveiling the results of trials testing the safety and efficacy of cannabidiol. The findings are largely promising. In the biggest study, the number of seizures went down by about half, on average, among children who completed the trial. Benefits for some continued even after the study was over.
“In the subsequent periods, which are very encouraging, 9 percent of all patients and 13 percent of those with Dravet Syndrome epilepsy were seizure-free,” Dr. Orrin Devinsky, the study’s lead author and a neurologist at the New York University Langone Medical Center, told NPR. “Many have never been seizure-free before.”
The data represent a significant step forward in legitimizing use of cannabis to treat epilepsy, a syndrome that in both children and adults causes debilitating seizures and can be especially difficult to treat. Patients sometimes exhaust traditional anti-seizure medications to no effect.
Despite the findings of CBD’s potential benefit in epilepsy treatment, the study results weren’t all good. In Devinsky’s three-month trial, 16 percent of participants withdrew due to adverse side effects or after deciding the treatment was ineffective. And in a yearlong study of 25 patients, one participant actually experienced more frequent seizures.
Participants in the studies didn’t smoke or vaporize cannabis flowers or concentrates. Rather, they consumed cannabidiol in the form of daily doses of purified extracts that had been derived from cannabis plants.
Parents across the country have turned to high-CBD strains after hearing about their sometimes life-changing benefits. Charlotte’s Web, for example, was developed in 2011 and popularized after it was used successfully to treat epileptic seizures in a Colorado girl, Charlotte Figi. While Figi’s story has encouraged lawmakers in some states to loosen regulations on high-CBD strains, many desperate parents still obtain the drug illegally. And because of a lack of scientific evidence to justify their decision, they often face stigma — not to mention the risk of jail time — for giving their children cannabis.
Until recently, clinical trials involving cannabis have been almost nonexistent. As a federally controlled substance, the drug has been impossible to study except with government approval. But as legalization spreads, information about the efficacy of cannabis in treating various ailments will likely become ever more available.
If you’re not familiar with Charlotte’s Web, watch this video about Charlotte Figi and her family:
Earth Science Tech Announces Positive Interim results from Trial with Former Professional Football Athletes Using ETST High Grade Hemp CBD (Cannabidiol)
Boca Raton, Nov. 19, 2015 (GLOBE NEWSWIRE) — BOCA RATON, FL / Earth Science Tech, Inc. (ETST) (“ETST” or “the Company”), a unique biotechnology publicly traded company focused on nutraceuticals, bioceuticals and dietary supplements, announces interim results from phase 1 in introducing the ETST line of Nutraceutical and Bioceutical products to former professional athletes.
Approximately 2 weeks ago, ETST initiated its breakthrough trial study involving former professional football players using its Hemp CBD Oil. On the first day participants answered a number of questions scaling the intensity of various pain symptoms. They were all given doses of high potency Hemp CBD Oil to administer for 30 days two times a day. On day 15, the participants answered another series of questions scaling their pain levels. These preliminary results suggest a marked improvement in the participants’ pain levels.
The Former players and current candidates will be requested to submit a report of their affected physical and mental health at the conclusion of this trial. ETST is very excited about the future health implications suggested by these initial results. Although this is a first step on a long road, ETST looks forward to conducting future trial studies with former professional athletes.
ETST High Grade Hemp CBD is derived from imported 100% industrial hemp. ETST High Grade Hemp CBD Products contain hundreds of micronutrients (phytonutrients). These include Terpenoids, Essential Oils and Antioxidants. The most dynamic are a group of compounds called Cannabinoids that have been found to exist in Hemp and the human body. In addition to the cannabinoids present in our industrial hemp oil extracts, there are also many other types of natural molecules and “plant” chemical compounds such as amino acids, sugars, vitamins, fatty acids (including omega 3 & 6), flavanoids, ketones, nitrogenous compounds, alkanes, alcohols, glycosides, pigments, hemp seed oil, water, and terpenes. The most common terpenes in our CBD oils are Beta-caryophyllene, Caryophyllene Oxide, Myrcene, Terpinolene, Bisabolol, Pinene, Nerolidol, Ocimene and Phytol. Hemp oil contains more essential fatty acids than any other plant.
To view Scientific Research and Data on Earth Science Tech (ETST) High Grade Hemp CBD (Cannabidiol) please visit http://www.earthsciencetech.com/scientific-research.
ETST invites all interested parties to contact the company at email@example.com in order to secure its “High Grade Hemp CBD (Cannabidiol) Oil” in bulk for wholesale, resale or distribution. From product formulating, mixing, labeling and launching ETST can do it all. ETST is always open to forming new strategic partnerships, joint ventures and/or supplying vendors, resellers and third party distribution companies with its High Grade Hemp CBD (Cannabidiol) Oil/Products at wholesale prices in order to better help supply consumers as well as the health and wellness markets on a large scale. You can view, research and purchase small quantities or bottles of ETST High Grade CBD (Cannabidiol) Rich Hemp Oil at http://www.earthsciencetech.com/cbd-rich-hemp-oil.
ETST is focused on the science, research and studies of its High Grade Hemp CBD Oil as a health and wellness, nutraceutical and dietary supplement. In order to assure the public that ETST provides the best High Grade Hemp CBD (Cannabidiol) Oil, we continue to focus on providing the public with sound scientific research and keeping the public informed on the progression of studies being done on our Hemp CBD products. ETST has engaged the expertise of a leading USA independent biological company and has been doing scientific research and studies with a University. Science is what will progress the future of ETST High Grade Hemp CBD (Cannabidiol) Oil and its products. Cannabidiol (CBD) is a naturally occurring constituent of industrial hemp oil. It is the most abundant non-psychoactive cannabinoid in hemp and is commonly used as a dietary supplement to support general wellness. ETST hemp derived, high CBD, full-spectrum phyto-cannabinoid oil blends are made from top quality, Grade-A European hemp cultivars, grown in pristine soil in choice European locations. ETST High Grade Hemp CBD oils are constantly analyzed for their purity and purity from potential contaminants. ETST encourages researching cannabidiol (CBD) from reliable informational sources to see what is being investigated and discussed about CBD oil. Numerous properties and benefits of CBD are being investigated at academic research centers in the United States and elsewhere. The FDA has not evaluated the validity or truthfulness of these claims; therefore, we encourage you to review published researches relating to the benefits and properties of CBD hemp oils and other CBD products.
Humans are designed with a built-in Endocannabinoid System (ECS): Research shows that many scientists believe cannabinoids work synergistically to support the whole human endo-cannabinoid system (internal and natural human cannabinoid system). It is your body’s way of communicating with itself and properly regulating the way every other body system functions from your brain to your toes. The Endocannabinoid System (ECS) has shown to control pain sensation, appetite, temperature regulation, stress reactivity, immune function, and sleep as well as other processes. Even more interesting is that muscle and fat tissue also utilize these receptors to control their processes. Consumers should think of the Endocannabinoid System as one of the body’s main control and command centers for tweaking your metabolism’s ability to react and adapt to the world around it. Like many other nutrients in our diet, Cannabinoids can become exhausted and in need of steady dietary replenishment. Scientific studies and data show that Hemp CBD (Cannabidiol) Oil as well as all micronutrients (phytonutrients) and phyto-cannabinoids found in the oil work in harmony with the human body’s own endocannabinoid system making a positive effect for overall wellness. Hemp oil contains CBD — a non-psychoactive compound of the plant. There are millions of hemp oil consumers around the world and this number is rapidly rising with an increasing number of reports and studies showing a variety of benefits of hemp oil.
ETST High Grade Hemp CBD (Cannabidiol): ETST High Grade Hemp CBD (Cannabidiol) Oil is formulated using a wide array of cutting-edge technologies. ETST’s High Grade Hemp CBD Oil is all-natural and derived completely from the federally legal industrial hemp plant. Industrial Hemp (Hemp) is not marijuana and will not get you ‘high’ and it does not require a medical license of any kind to authorize purchase. It is lab tested multiple times during the manufacturing process, from seed to shelf. This also includes being tested for CBD content, other Cannabinoid content, yeast/mold/fungus, and bacteria like E. coli to ensure safety and top quality. ETST believes that Hemp CBD Oil awareness today is where Omega 3 and Omega 6 fatty acids were 15 to 20 years ago. One of ETST’s pertinent objectives is to help consumers Worldwide with their overall wellness through advanced formulations with its High Grade Hemp CBD (Cannabidiol) Oil and other cutting edge nutraceuticals and dietary supplements. Hemp CBD Oil is poised to be the most renowned and effective natural compound and botanical alternative introduced to the nutritional and dietary supplement industry in decades. Consumers worldwide desperately need more effective safe botanical alternatives to help them with their overall health and internal wellness. Modern science has identified over 400 phytonutrients in various parts of the industrial hemp plant. These include hundreds of Terpenoids, Essential Oils and Antioxidants but perhaps the most dynamic are a group of 80 compounds called Cannabinoids that are exclusively found in Hemp and one other place; our bodies. There are roughly 80 different phyto-cannabinoids, most prominently CBD, CBC, CBG, CBN, and most likely others yet to be effectively identified. In addition to the cannabinoids present in High Grade Hemp CBD (Cannabidiol) Oil extracts, there are also many other types of natural molecules such as amino acids, fatty acids, flavonoids, ketones, nitrogenous compounds, alkanes, alcohols, glycosides, pigments and terpenes among other things. The most common terpenes in our Hemp CBD oils are Beta-caryophyllene, Caryophyllene Oxide, Myrcene, Terpinolene, α Bisabolol, α Pinene, Nerolidol, Ocimene and Phytol.
About Earth Science Tech, Inc. (ETST): Earth Science Tech (www.earthsciencetech.com) is a publicly traded (symbol: ETST) unique Science based Biotechnology company focused on cutting edge Nutraceuticals, Bioceuticals, Phytoceuticals and Cosmeceuticals for the Health, Wellness and Alternative Medicine Markets to help improve the quality of life for Consumers Worldwide. ETST is also dedicated to providing Natural Alternatives to prescription medications through the use of its cutting edge Nutritional and Dietary Supplements. This may include products such as its High Grade Hemp CBD (Cannabidiol) Oil, Vitamins, Minerals, Herbs, Botanicals, Personal Care Products, Homeopathies, Functional Foods and other products. These products may be in various formulations and delivery systems including (but not limited to) capsules, tablets, soft gels, chewables, liquids, creams, sprays, powders, and whole herbs. ETST is focused on researching and developing innovative Hemp extracts and to make them accessible Worldwide. ETST plans to be the premier supplier of the highest quality and purity of High Grade Hemp CBD (Cannabidiol) Oil. ETST’s primary goal is to advance different High Quality Hemp extracts with a broad profile of Cannabinoids and additional natural molecules found in Industrial Hemp and to identify their distinct properties. The company is dedicated in offering its consumers the finest and purest quality All Natural-Organic Hemp CBD Oil while never compromising on quality. ETST High Grade Hemp CBD (Cannabidiol) Oil is classified as “food based” and therefore perfectly permissible in all 50 states and more than 40 countries. Cannabinoids (Cannabidiol/CBD) are natural constituents of the Hemp plant and CBD is derived from Hemp stalk and seed. Hemp oil is a well-known dietary supplement and the naturally occurring CBD possesses no psychoactive qualities and presents a continuing stream of overwhelming evidence of significant Wellness benefits. With no psychoactive ingredient, Hemp CBD Oil is a ready-for-market Hemp-based Nutraceutical. The United States Food and Drug Administration (FDA) currently considers non-THC hemp based cannabinoids, including CBD, to be “food based” and therefore saleable. These new non-psychoactive CBD-rich hemp oil products that ETST has geared up to market and distribute are beyond reproach. CBD (cannabidiol), a naturally occurring constituent of the Industrial Hemp plant, promotes and supports the nutritional health of aging bodies in particular. Source: US Government Patent #6,630,507 “Cannabinoids as antioxidants and neuroprotectants.” ETST does not grow, sell or distribute any substances that violate United States Law or the controlled substance act. ETST does sell and distribute hemp based products.
Make sure to visit ETST at:
ETST Corporate Website: www.earthsciencetech.com
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In a study with ten male cannabis users THCV (tetrahydrocannabivarin) inhibited some THC effects, researchers of the Institute of Psychiatry of King’s College in London, UK, wrote in the Journal of Psychopharmacology. 10mg oral pure THCV or placebo were administered daily for five days, followed by 1mg intravenous THC on the fifth day.
THCV was well tolerated and subjectively indistinguishable from placebo. THC did not significantly increase psychotic symptoms, paranoia or impair short-term memory, while still producing significant intoxicating effects. Recall of presented words was impaired by THC and only occurred under placebo condition suggesting a protective effect of THCV. THCV also inhibited THC-induced increased heart rate. Nine out of ten participants reported THC under THCV condition to be subjectively weaker or less intense compared to placebo.
Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. J Psychopharmacol. 2015 Nov 17. [in press]
By next summer, some North Carolina farm fields could be filled with cannabis plants – not marijuana, but hemp, which is marijuana’s near-twin in appearance but has little of the ingredient that makes people high.
For the first time in decades, hemp will be a legal crop in this state.
Initially it’s to be grown only on an experimental basis. But hemp advocates hope North Carolina will become part of a national revival of a hemp industry that was knocked down in the 20th century when hemp was lumped in with marijuana by national and local laws against illicit drugs.
The 21st-century American hemp revival is somewhat reminiscent of Colonial times. In the 1700s, according to historical records, leaders in North Carolina and other English colonies in North America encouraged farmers to grow hemp. They aimed to generate income with exports.
In 1766, North Carolina’s legislature voted to open a hemp-inspection warehouse in Campbellton, one of the two towns that later merged and became Fayetteville. A journal of the legislative session says the lawmakers also renewed for four years a bounty paid to hemp farmers.
More than two centuries later, North Carolina and the United States were importing all of their hemp products. After encouraging hemp production during World War II to supply the military with rope and other materials, the government effectively banned hemp farming in 1970. The last known American commercial crop was reported to have been grown in Wisconsin in 1957, according to The Denver Post newspaper.
In early 2014, Congress and the president approved a law to allow experimental hemp farming in states that conduct agricultural research. North Carolina’s lawmakers voted nearly unanimously in late September to join this effort. The legislation, which emerged with little warning or opportunity for vetting or public comment in the final days of the 2015 lawmaking session, creates the opportunity “to study the growth, cultivation, or marketing of industrial hemp.”
Including North Carolina, 27 states are pursuing hemp production, says the Vote Hemp Inc. advocacy group.
That’s great news for people such Brenda Harris, who operates the The Apple Crate Natural Market health food stores in Fayetteville and Hope Mills. The hemp seed, hemp-based protein powders and hemp-based soaps, lotions and oils on her shelves are imported from Canada and overseas.
Hemp seed is high in protein, Harris said, and in essential fatty acids that people need for good health.
Cannabidiol, also known as CBD oil, is reported to reduce nausea, suppress seizures, help with cancer, tumors, anxiety and depression and other health problems, says the Leaf Science website. But it notes that most of the studies that made these findings were with animals, not people.
In addition, hemp can be used in a number of fiber-based products.
“I’d love to know my dollars were supporting a North Carolina farmer,” Harris said.
“It will definitely mean the product will be more competitively priced,” she said. “And it’s not a terribly expensive product to start with, but still I feel like with bringing that closer to home, it’ll be more sustainable, there’ll be less shipping involved, there’ll be less mark-up involved. That’s usually the way the chain works.”
Organic farmer Lee Edwards of Kinston, about 90 minutes east of Fayetteville, could become one of Harris’ North Carolina suppliers.
Edwards plans to become part of North Carolina’s hemp pilot project and get a crop into the ground in mid-2016. He thinks hemp will make more money than the corn, wheat, soybeans and cereal grains he grows now.
“It’s a lower input cost and a higher profit per acre crop,” Edwards said. He estimated hemp could net him $1,250 per acre after expenses versus the $400 at most “on a real good year” from traditional grains. And he hopes that he can get two hemp crops a year.
Las Vegas-based Hemp Inc. opened a processing plant last year in Spring Hope, between Raleigh and Rocky Mount. It has been extracting fiber from kenaf, which is similar to hemp (and never was banned), and plans to process hemp as it becomes legal and available in the U.S.
The decortication plant extracts fibers that can be used in paper, clothing and other fiber-based products, even car parts and building materials, according to the Hemp Inc. website.
Back in Fayetteville, researcher Shirley Chao and her students at Fayetteville State University might be able to get North Carolina-grown hemp seed for their research into a hemp-derived insecticide. Until now, they have been buying imported seed.
Over the past several years, Chao and her students discovered that chemicals in hemp have a variety of detrimental effects on roaches, carpenter ants and grain-eating beetles.
“We found that it’s very effective in controlling reproduction,” Chao said. “And when they feed on it, they don’t develop normally. And so they, most of them, either die or have these deformations that you can see. And then if they do survive, they don’t reproduce normally.”
Chao hopes that further research will demonstrate that the hemp-based pesticide has no ill effects on people or other vertebrates. That quality could make it preferable to other pesticides in use today.
The school also is seeking a patent for the pesticide.
Before anyone buys hemp legally grown in North Carolina, the state has to set up its system to regulate it and issue hemp-growing licenses to the farmers.
That process is not moving as quickly as advocates would like.
The new hemp law says a state commission must be set up to license and regulate the growers. But first, the industry has to raise $200,000 in private donations to pay for the commission.
As of mid-November, about $20,000 had been raised, said Thomas Shumaker, the executive director of the N.C. Industrial Hemp Association.
Shumaker’s group led the effort at the legislature this year to pass the hemp law.
Once the money is raised, a five-person N.C. Industrial Hemp Commission will be appointed to set up the state’s hemp program, the law says. It is to work with federal law enforcement or other federal agencies as appropriate, vet people seeking licenses and set rules for how the program will operate.
Because of law enforcement concerns, the GPS coordinates of every hemp farm will be noted, and the hemp will be subject to testing to ensure that it isn’t actually marijuana. Under the law, hemp plants must have no more than 0.3 percent THC content, the psychoactive chemical that makes marijuana users high.
Marijuana typically has 5 to 20 percent THC and the highest grades carry 25 to 30 percent, Leaf Science says.
It will probably be June before North Carolina’s hemp regulatory system is in place and farmers can start planting, Shumaker said.
Learning from others
In the meantime, the state’s farmers can learn from growers in several other states who have been experimenting with hemp.
Kentucky just finished its second year of its pilot project. It had 922 acres planted in 2015, said Adam Watson, the industrial hemp program coordinator for the Kentucky Department of Agriculture.
The state is looking at different varieties of hemp for grain (the seeds), fiber and nutraceuticals, which are oils that are thought to have health benefits.
The program has worked with with law enforcement, Watson said. Police know the growers have hemp, not marijuana, he said, but some thieves didn’t know the difference and went into a field and stole some.
Farmers have tested seed from Canada, Australia and Europe, he said. They are allowed to sell their harvest, but it’s too soon to figure out yet the extent of the potential market, he said.
While hemp can be used to make paper, textiles, building materials and other items, it may not necessarily be the best raw material for those products, Watson said. Much depends on whether the hemp-based products prove to be practical and cost-effective, he said.
Watson and other industry observers said the American hemp industry is in a chicken-and-egg situation in getting started: Because there have been no growers, there is no marketplace or infrastructure to buy their product. But without growers, there is no incentive to set up a marketplace.
But there is demand for hemp.
The Congressional Research Service this year estimated that in 2013, the United States imported $36.9 million in hemp products. The Hemp Industries Association estimated that the total U.S. retail value of hemp products in 2013 was $581 million, the research service said.
People like Edwards, the farmer from Kinston, want a piece of that market.
“I hope to start with around 50 acres,” Edwards said. “That’s more of just getting going the first year. Depending on how things go, I’d love to get up to a couple hundred acres.”
A research team at Washington State University has been developing a breathalyzer that could accurately detect whether a driver is under the influence of marijuana.
Police officers use blood tests to determine if a driver has THC in their system, usually administered at the police station. Blood tests can take up to 24 hours for results.
In Washington state where recreational marijuana is legal, Initiative 502 set the legal limit for 5 nanograms of active THC per mililiter of blood.
Currently, police officers are limited in their choices of reliable portable THC measurement technology in the field. Washington state cops have indicated they would be open to a new portable breathalyzer, but only if it was accurate and reliable.
WSU Chemistry professor Herbert Hill is leading the research team through a second round of testing with the goal of making their marijuana breathalyzer available in 2016.
Hill says the test is designed for immediate accurate results for THC, not the metabolite that is more likely to stay in a person’s system for weeks, and can give false positives.
New research on the cannabinoid THCV shows that it may reduce the effects of THC.
While almost all marijuana users are familiar with the effects of THC, new findings show why you may want to pay attention to another compound known as tetrahydrocannabivarin (THCV).
THCV is one of many cannabinoids found in cannabis and is often measured during laboratory testing. But up until now, little was known about the effects of THCV — both psychological and otherwise.
Interestingly, a new study published Nov. 17 in the Journal of Psychopharmacology seems to show that THCV works against THC to dampen the high.
While the sample size was small — the study only involved 10 participants — the results showed that combining doses of THCV with THC overwhelmingly resulted in a high that felt “less intense” compared to THC alone.
THCV also seemed to protect against other common effects of THC, including memory impairment and increased heart rate.
Interestingly, THCV seemed to have no psychoactive effect when taken alone. In fact, participants in the study were unable to distinguish doses of THCV from a placebo.
The authors — a group of scientists from King’s College London — say that this seems to contradict older research published in the 1970s, which suggested THCV might have weak psychoactive properties.
Nevertheless, the latest findings suggest that THCV may offer a similar sort of protection as CBDwhen it comes to reducing the psychoactive effects of cannabis.
According to testing results from the 2014 High Times Cannabis Cup in Seattle, many sativa strains have noticeable levels of THCV. In fact, this may explain the uplifting and energizing effect that sativa strains are known for.
So, for the growing number of people seeking marijuana with a less potent high, strains with significant THCV levels may be a good place to start.
A controlled animal study published in Daru: Journal of Faculty and Pharmacy, Tehran University of Medical Sciences found that topical treatment with 1% purified (i.e. >98%) CBD topical cream may help to reduce damage caused by a disease that results in brain inflammation. This holds relevance for humans with autoimmune diseases that lead to demyelination (damage to the fatty covering around neurons that helps them to transmit signals faster) like multiple sclerosis.
Topical CBD vs. Multiple Sclerosis Experiment
Using healthy mice and mice with experimental autoimmune encephalomyelitis[(EAE)- encephalo= brain, myel= myelin= fatty nerve covering, itis= inflammation] as models for humans with multiple sclerosis, researchers applied either 1% purified CBD cream, inactive cream, or no cream to the skin of the healthy mice, and to the skin of diseased mice once symptoms of EAE began to appear. The mice were observed daily, and 28 days after EAE had been induced, spinal cord and spleen cell samples were taken.
Results of the Study
The researchers found that treatment with CBD cream helped to reduce damage caused by EAE, characterized by:
- reversal of back leg paralysis (i.e. loss of muscle function)
- reduction in indicators of spinal cord damage like demyelination and white blood cell count
- reduction in release of lymphocytes from spleen cells
- reduction in inflammatory signals
The results of this study provide further support for the potential of cannabinoids in reducing damage caused by autoimmune/inflammatory diseases like multiple sclerosis. More uniquely, however, they show that cannabinoids may produce beneficial biological effects even when only applied to the skin, as opposed to typical internal administration (e.g. edibles, vaping, smoking).
Agradecemos a todas las personas que vean el video sobre el proyecto de investigación “Cannabis Oil Experiment Fund” sobre los beneficios medicinales de los cannabinoides. Este gran proyecto es creado por Jeff Dicthfield con la colaboración del Dr. Manuel Guzmán, Profesor de la Universidad Complutense de Madrid.
Están buscando donaciones para poder continuar con la investigación, así que damos las gracias a aquellas personas que puedan hacer un donativo.
We thank the people who watch the video on the research project “Experiment Cannabis Oil Fund” on the medicinal benefits of cannabinoids. This major project is created by Jeff Dicthfield with the collaboration of Dr. Manuel Guzman, professor at the Complutense University of Madrid.
They are seeking donations to continue the investigation, so thank you to those who can make a donation.