A controlled animal study published in Daru: Journal of Faculty and Pharmacy, Tehran University of Medical Sciences found that topical treatment with 1% purified (i.e. >98%) CBD topical cream may help to reduce damage caused by a disease that results in brain inflammation. This holds relevance for humans with autoimmune diseases that lead to demyelination (damage to the fatty covering around neurons that helps them to transmit signals faster) like multiple sclerosis.
Topical CBD vs. Multiple Sclerosis Experiment
Using healthy mice and mice with experimental autoimmune encephalomyelitis[(EAE)- encephalo= brain, myel= myelin= fatty nerve covering, itis= inflammation] as models for humans with multiple sclerosis, researchers applied either 1% purified CBD cream, inactive cream, or no cream to the skin of the healthy mice, and to the skin of diseased mice once symptoms of EAE began to appear. The mice were observed daily, and 28 days after EAE had been induced, spinal cord and spleen cell samples were taken.
Results of the Study
The researchers found that treatment with CBD cream helped to reduce damage caused by EAE, characterized by:
- reversal of back leg paralysis (i.e. loss of muscle function)
- reduction in indicators of spinal cord damage like demyelination and white blood cell count
- reduction in release of lymphocytes from spleen cells
- reduction in inflammatory signals
The results of this study provide further support for the potential of cannabinoids in reducing damage caused by autoimmune/inflammatory diseases like multiple sclerosis. More uniquely, however, they show that cannabinoids may produce beneficial biological effects even when only applied to the skin, as opposed to typical internal administration (e.g. edibles, vaping, smoking).
Agradecemos a todas las personas que vean el video sobre el proyecto de investigación “Cannabis Oil Experiment Fund” sobre los beneficios medicinales de los cannabinoides. Este gran proyecto es creado por Jeff Dicthfield con la colaboración del Dr. Manuel Guzmán, Profesor de la Universidad Complutense de Madrid.
Están buscando donaciones para poder continuar con la investigación, así que damos las gracias a aquellas personas que puedan hacer un donativo.
We thank the people who watch the video on the research project “Experiment Cannabis Oil Fund” on the medicinal benefits of cannabinoids. This major project is created by Jeff Dicthfield with the collaboration of Dr. Manuel Guzman, professor at the Complutense University of Madrid.
They are seeking donations to continue the investigation, so thank you to those who can make a donation.