Publicaciones de la categoría: Science

French Drug Trial Tested Endocannabinoid Meds, Not Cannabis

The big health news Friday was that a botched drug trial in France had left four people with “irreversible” brain damage. One man is now brain dead and at least five others have been hospitalized, according to the latest reports.

Before details about the trial drug could be confirmed, AFP, France’s largest news agency, quoted an unnamed source “close to the case” who claimed the painkiller under trial contained cannabis. The story spiraled from there, picked up by panicked news media in France and the U.K. and spreading across the Internet.

RT dubbed the clinical trial “cannabis-laced.” Vice News screamed that “The Drug Trial of a Cannabis Painkiller Has Left One Person Brain Dead.”

Let’s be clear: That’s not true.

Shortly after the news broke, French Health Minister Marisol Touraine began correcting erroneous reports. The drug being tested, she said, contains neither cannabis nor cannabis derivatives.

Developed by the Portuguese pharmaceutical company Bial and tested in France by Biotrial, the drug in question is intended to address mood, anxiety and motor problems linked to neurodegenerative diseases. It works by affecting the endocannabinoid system, a set of brain receptors that cannabis interacts with. But there are other known substances, beyond cannabis, that affect the endocannabinoid system.

Is Your Endocannabinoid System in Balance?

Media outlets quickly revised their headlines and stories, but the damage had been done. When it comes to cannabis, deeply-rooted fears have a tendency to seek out reinforcing evidence, no matter how erroneous that evidence may turn out to be. Pairing “cannabis drug” with “brain damage” creates a sticky meme that’s tough to un-stick.

Here’s the story you’re not hearing. There’s currently a scramble going on among researchers and pharmaceutical companies to develop non-cannabis drugs that affect the endocannabinoid system. FAAH and MAGL inhibitors in particular have shown promise as non-cannabis enzymes that could interact with the endocannabinoid system to produce healing results. Bial’s experimental drug could be part of that effort — or not. We don’t know enough about the trial drug yet to say for sure.

All of this begs the question: Why develop non-cannabis drugs when the plant is already available? One possibility: Proprietary drugs and patents. If you invent it and patent it, you own it. Nobody owns Charlotte’s Web or Harlequin.

La Jolla, California-based Abide Therapeutics, for instance, is developing a small-molecule inhibitor that interacts with the body’s endocannabinoid system and could potentially treat pain and neuroinflammation. (To be clear: Abide has no connection to the news out of France.) You can read more about Abide’s effort here.

We’ll continue to follow the story out of France as it develops, and we’ll also continue to look into developments in endocannabinoid research, both cannabis-related and non-cannabis-related. Stay tuned.


Can Marijuana Help with Depression?

cannabis-depression-salvados asociacion

Medical research suggests that cannabis may help improve mood, but users also seem to suffer higher rates of depression.

Marijuana is sometimes referred to as ‘green Prozac’ due to the fact that many users find it helpful in lifting their spirits. But can it actually be an effective treatment for depression?

Interestingly, the idea that cannabis can be used to improve mood goes back hundreds of years. And many people today still agree.

“A lot of people report using cannabis effectively to treat depression,” says Zachary Walsh, an assistant professor of psychology at the University of British Columbia who heads a research lab focused on marijuana and mental health.

But whether cannabis has actually been proven to help with depression can’t be answered with a simple yes or no. The answer is more complicated because there are different types of depression, explains Walsh.

Generally speaking, depression is defined as the feeling of sadness or hopelessness over an extended period of time.

Studies on Marijuana and Depression

For depression that is caused by chronic stress, components of marijuana may be an effective treatment, according to a 2015 study by University of Buffalo scientists. The findings showed that stress caused a decrease in cannabis-like molecules naturally found in the brain, leading to behavior that mimicked depression.

Another study published in 2007 by a team at McGill University showed that administering low doses of THC could work like an antidepressant by increasing serotonin. However, in high dosages, THC decreased serotonin and seemed to worsen depression.

“These findings confirm what has been reported by people who smoke cannabis,” explains Dr. Gabriella Gobbi, who co-authored the McGill study. “Often it produces euphoria, calmness, sociability, but in other circumstances it can produce bad dreams and negative feelings.”

Overall there hasn’t been enough research in the field, Dr. Gobbi says, adding that the type of research needed to confirm whether marijuana can effectively treat depression is quite complex.

“Not only do we have to determine the dose-effect of cannabis on depressive people, but also which kind of cannabinoid may have a positive effect on mood.”

Cannabinoids are a class of molecules found in cannabis, which include THC and CBD. Over 60 different cannabinoids have been identified in marijuana, making it difficult to determine the drug’s overall effect on depression.

Higher Rates of Depression

While medical literature suggests that cannabis can improve mood, studies involving recreational users often show that people who use cannabis are more depressed, says Walsh.

“What those studies have noted is that they can’t really determine what comes first,” he explains. In other words: “Does cannabis cause depression? Do depressed people try to use cannabis to help with depression? Those are questions that are out there.”

An important factor in the answer could be the age of the person consuming cannabis.

According to research conducted by Dr. Gobbi in 2009, daily use of marijuana can cause depression and anxiety in teens.

“Cannabis, when consumed by adolescents, induces depression and anxiety later in adulthood, even if the people did not have any susceptibility for these mental diseases,” she says.

Cannabis vs. Antidepressants

While researchers can’t completely confirm if marijuana is effective for treating depression, Walsh points out that other medicines fall into the same problem.

He says that in some cases, typical antidepressants are no more effective than a placebo and have side effects that may be more severe than those of marijuana.

Dr. Gobbi explains that in order to declare a drug effective for a certain disease, it must go through different stages of clinical trials, which marijuana has not.

“If we want to take a rational approach about medicinal cannabis, we should go through systematic clinical studies and finally determine its efficacy in treating specific diseases and its safety compared to standard antidepressants,” she says.

Walsh agrees that further research should compare cannabis to commonly used antidepressants. “Then I think people can make the choice,” he concludes.


Source: Leafscience