In a study with ten male cannabis users THCV (tetrahydrocannabivarin) inhibited some THC effects, researchers of the Institute of Psychiatry of King’s College in London, UK, wrote in the Journal of Psychopharmacology. 10mg oral pure THCV or placebo were administered daily for five days, followed by 1mg intravenous THC on the fifth day.
THCV was well tolerated and subjectively indistinguishable from placebo. THC did not significantly increase psychotic symptoms, paranoia or impair short-term memory, while still producing significant intoxicating effects. Recall of presented words was impaired by THC and only occurred under placebo condition suggesting a protective effect of THCV. THCV also inhibited THC-induced increased heart rate. Nine out of ten participants reported THC under THCV condition to be subjectively weaker or less intense compared to placebo.
Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. J Psychopharmacol. 2015 Nov 17. [in press]